Kinetics of the human renin and human substrate reaction

Abstract

The Michaelis constant (Km) for the hydrolysis of human renin substrate by human renin is 0·931 n-mole/ml. This concentration of substrate is higher than that found in a normotensive population. Since the Km is numerically equal to the concentration of substrate that will permit the reaction to proceed at half its maximal velocity, substrate concentration in normal serum occurs at a very critical level.