Acid stimulates E-cadherin surface expression on gastric epithelial cells to stabilize barrier functions via influx of calcium

Abstract

These findings suggest that E-cadherin expression on gastric epithelium stabilizes the epithelial barrier against acid, probably through influx of [Ca2+]. This event is thought to be one of the protective mechanisms in gastric mucosa against acid back-diffusion, which is one of the causes of peptic ulcer formation.