Applied Physics Letters · 2014 · 21 citations · 18 references
MedicineCancer BiologyOncologyApoptosisMetastasisTumor MicroenvironmentAngiogenesisAngiogenesis In CancerEndothelial ActivationEndothelial DysfunctionMetastatic Disease TreatmentMetastatic DisseminationAngiogenesis In NeoplasmsApoptosis Of Endothelial CellsAtmospheric PressureAtmospheric Pressure Plasma TreatmentCell Cycle Arrest MechanismsCell Cycle Arrest SignalingTumor NeovascularizationTumor Vascular Normalization
Atmospheric pressure plasma (APP) has been recognized as a promising tool for cancer therapy based on its ability to remove cancer cells by causing apoptosis and necrosis. However, the effect of APP on the neighboring tissues of tumors remains unknown. Moreover, the role of APP on the vessels near tumors could be very important, because once a tumor becomes vascularized, the potential for metastasis can increase dramatically. We show in the present study that APP can induce cell cycle arrest in endothelial cells and further suppress the angiogenesis process. These results strongly support the use of APP in cancer treatment.
18
WAF1, a potential mediator of p53 tumor suppression
Wafik S. El‐Deiry, Takashi Tokino, Victor E. Velculescu et al. · Cell · 1993 · 8.4K citations
Requirement for p53 and p21 to Sustain G <sub>2</sub> Arrest After DNA Damage
Fred Bunz, Annie Dutriaux, Christoph Lengauer et al. · Science · 1998 · 2.8K citations
Gregory Fridman, Gary Friedman, Alexànder Gutsol et al. · Plasma Processes and Polymers · 2008 · 2.1K citations