Oligothymidylates: Formation by Thermal Condensation of <i>O</i> ² ,5′-Cyclothymidine 3′-Phosphate

Abstract

Thermal activation of O(2),5'-cyclothymidine 3'-phosphate in solution and in the solid state led to the formation of thymidine oligonucleotides containing up to approximately 12 nucleotide units. Only the 3',5' internucleotide diester bonds were formed. This polymerization occurs without the addition of any activating agent or catalyst.