Hyaluronan-based Biomaterials in Tissue Engineering

Abstract

There has been an increasing interest in reabsorbed or degradable biomaterials with hyaluronan (HA)-based high molecular polymers in tissue engineering techniques, where scaffold biomaterials are used as a career matrix, and materials of culture cells or three-dimensional tissue reconstruction. Clinical application of biopolymers has been described using different molecular engineering strategies involving a variety of biosynthetic and modified natural polymers like ECM molecules including hyaluronan and glucosaminoglycans. The present report attempts to evaluate HA-based biomaterials as reconstructive or augmentation materials for repair tissue loss or great tissue damage. Excellent histocompatibility and biodegradability in HA-based biomaterials as HYAFF® are achieved in cases of synthetic bioskin and biosynthetic osteo-cartilage tissues for tissue reconstruction. A variety of growth factors and cytokines have also served to promote cell migration, proliferation and new tissue formation onto biomaterials.