Cold Spring Harbor Symposia on Quantitative Biology · 1983 · 371 citations · 0 references
Life SciencesGeneticsMolecular BiologyDna ReplicationGenome OrganizationStructural BiologyGenome DuplicationReplication In EukaryotesReplication InitiationReplication OriginsS PhaseWhole-genome DuplicationGenome-wide Mapping Of Replication OriginsOric Replication OriginReplication Initiation ComplexReplication Initiation In EukaryotesReplication Origin ActivityReplication Origin StructureReplication Origins In EukaryotesSequence Determinants Of Replication Origins
The precise and uniform duplication of a cell's genome is essential to its normal growth. Focal points for the orchestration of this central process are provided by specific loci within the genome that function as sites of initiation of DNA replication. In this paper we present results that allow us to address the structural characteristics of DNA replication origins in yeast.