Journal of the American Medical Association · 1920 · 35 citations · 0 references
AgricultureNutritionNutritional SciencesAnimal NutritionClinical NutritionMicronutrient DeficiencyFat-soluble VitaminsNutritional DeficienciesNutritional Deficiency DiseasesNutritional DisordersVitamin BiochemistryVitamin PhysiologyAcute Disease PathogenesisDietary Deficiency DisordersExperimental Results InterpretationFat-soluble Vitamin HomeostasisFat-soluble Vitamin Metabolism
In the last few years, the subject of deficiency diseases has become one of absorbing interest for both the laboratory investigator and the clinician. In order that the advances in this field may proceed on firm ground, it will be necessary that step by step we compare and correlate experimental results with clinical experience. Perhaps the largest amount of work has been carried out on scurvy, both in this country and abroad, and has brought forth results that coincide remarkably for animals and for man. All diets leading to scurvy in the guinea-pig produce scurvy in man; all antiscorbutics are potent for both species; all signs and symptoms of the disease are common in some degree to both guinea-pig and man. There is, however, one important difference, namely, that in man the disorder is a slow, markedly subacute process, whereas in the guinea-pig it is almost an acute disease. This