Publication | Closed Access
A Concise Total Synthesis of Antifungal Antibiotic (+)‐Preussin
31
Citations
41
References
2006
Year
Bioorganic ChemistryOrganic ChemistryChemistryConcise Total SynthesisMedicinal ChemistryImportant Natural ProductStereoselective SynthesisAntifungal AgentsDiversity-oriented SynthesisAntimicrobial CompoundNatural Product SynthesisPharmacologyAsymmetric CatalysisEnantioselective SynthesisAntifungal AgentAntibioticsNatural SciencesShort SynthesisBinaphthol‐derived Asymmetric CatalystsMedicineSynthetic Chemistry
Abstract A short synthesis of the pharmacologically important natural product (+)‐preussin is described. Two asymmetric C–C bond‐formation reactions mediated by binaphthol‐derived asymmetric catalysts have been applied to control the stereochemistry of its three stereocenters. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)
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