Oral Benzo[a]pyrene in Cyp1 Knockout Mouse Lines: CYP1A1 Important in Detoxication, CYP1B1 Metabolism Required for Immune Damage Independent of Total-Body Burden and Clearance Rate

Development and Validation of Real-Time Quantitative Reverse Transcriptase–Polymerase Chain Reaction for Monitoring Gene Expression in Cardiac Myocytesin Vitro

Jane Winer, Christopher Kwang S. Jung, Irene Shackel et al. · Analytical Biochemistry · 1999 · 1.4K citations

Life Sciences, Cell Biology, Molecular Biology +10

Cytochrome P450 2C is an EDHF synthase in coronary arteries

Beate Fißlthaler, Rüdiger Popp, Ladislau Kiss et al. · Nature · 1999 · 910 citations

Medicine, Cardiology, Pharmacology +8

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

Tsutomu Shimada, Carrie L. Hayes, Hiroshi Yamazaki et al. · PubMed · 1996 · 795 citations

Pharmacy, Biochemistry, Toxicology +17

Cytochrome P450 CYP1B1 determines susceptibility to 7,12-dimethylbenz[ <i>a</i> ]anthracene-induced lymphomas

Jeroen Buters, Shuichi Sakai, Thomas Richter et al. · Proceedings of the National Academy of Sciences · 1999 · 387 citations · Full text

Medicine, Genetics, Pharmacology +12

Oral Exposure to Benzo[a]pyrene in the Mouse: Detoxication by Inducible Cytochrome P450 Is More Important Than Metabolic Activation

Shigeyuki Uno, Timothy P. Dalton, Sandrine Derkenne et al. · Molecular Pharmacology · 2004 · 313 citations

Pharmacy, Pharmacology, Toxicology +17