The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

William E. Carson, Judith G. Giri, M J Lindemann et al. · The Journal of Experimental Medicine · 1994 · 1.1K citations · Full text

Innate Immune System, Immunology, Immune Regulation +18

NF-κB Function in Growth Control: Regulation of Cyclin D1 Expression and G ₀ /G ₁ -to-S-Phase Transition

M. Hinz, Daniel Krappmann, Alexandra Eichten et al. · Molecular and Cellular Biology · 1999 · 780 citations · Full text

Differential Cytokine and Chemokine Gene Expression by Human NK Cells Following Activation with IL-18 or IL-15 in Combination with IL-12: Implications for the Innate Immune Response

Todd A. Fehniger, Manisha H. Shah, Matthew J. Turner et al. · The Journal of Immunology · 1999 · 639 citations · Full text

Secrete Cytokines, Innate Immune System, Immunology +19

Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy

T. A. Waldmann · Immunity · 2001 · 435 citations

Inflammation, Allergy, Autoimmune Disease +9

A novel population of expanded human CD3+CD56+ cells derived from T cells with potent in vivo antitumor activity in mice with severe combined immunodeficiency.

Peihua Lu, Robert S. Negrin · The Journal of Immunology · 1994 · 432 citations