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Application of polyamide resins to polypeptide synthesis: an improved synthesis of β-endorphin using fluorenylmethoxycarbonylamino-acids
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1978
Year
Product PurityEngineeringPeptide EngineeringOrganic ChemistryPeptide SciencePeptide TherapeuticsPeptide ChemistryPolymer ChemistryBiochemistryPharmacologyLipopeptidesBiomolecular EngineeringPolymer ScienceSynthetic BiologyPeptide SynthesisProtein EngineeringPolyamide ResinsMedicineImproved SynthesisPolymer Synthesis
Use of base-labile fluorenylmethoxycarbonyl-amino-acids enables solid phase peptide synthesis of human β-endorphin to be carried out under much milder reaction conditions than formerly with improvement in product purity and yield.