Methotrexate Chemotherapy Promotes Osteoclast Formation in the Long Bone of Rats via Increased Pro-Inflammatory Cytokines and Enhanced NF-κB Activation

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

Young‐Yun Kong, Hiroki Yoshida, Ildiko Sarosi et al. · Nature · 1999 · 3.4K citations

Medicine, Cell Biology, Immunology +14

TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

Jonathan Lam, Sunao Takeshita, Jane E. Barker et al. · Journal of Clinical Investigation · 2000 · 1.4K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

Kanichiro Kobayashi, Naoyuki Takahashi, Eijiro Jimi et al. · The Journal of Experimental Medicine · 2000 · 1.3K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Requirement for NF-κB in osteoclast and B-cell development

Guido Franzoso, Louise Carlson, Lianping Xing et al. · Genes & Development · 1997 · 994 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of C-Fms and Receptor Activator of Nuclear Factor κb (Rank) Receptors

Fumio Arai, Takeshi Miyamoto, Osamu Ohneda et al. · The Journal of Experimental Medicine · 1999 · 691 citations · Full text

Life Sciences, Cell Biology, Immunology +16