Soluble Factor(s) Released from Neutrophils Activates Endothelial Cell Matrix Metalloproteinase-2

Abstract

PMNs release a soluble factor that activates endothelial cell MMP-2 through a novel mechanism independent of cell-cell contact and not attributable to the activities of plasmin, cysteine-, acid-, or metalloproteinases. These findings may provide insight into the tissue remodeling that accompanies PMN-mediated microvascular injury.