Prostacyclin does not affect insulin secretion in humans

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

John R. Vane · Nature New Biology · 1971 · 8.6K citations

Life Sciences, Medicinal Chemistry, Pharmacology +10

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

Salvador Moncada, E.A. Higgs, John R. Vane · The Lancet · 1977 · 887 citations

Medicine, Hematology, Pharmacology +13

Increased Synthesis of Prostaglandin-E-like Material by Platelets from Patients with Diabetes Mellitus

Perry V. Halushka, Dan Lurie, John A. Colwell · New England Journal of Medicine · 1977 · 199 citations

Medicine, Biochemistry, Endocrinology +17

Circulatory and anti-platelet effects of intravenous prostacyclin in healthy men

Andrzej Szczeklik, Ryszard J. Gryglewski, Rafał Niżankowski et al. · Pharmacological Research Communications · 1978 · 180 citations

Medicine, Hematology, Pharmacology +14

A Role for Prostaglandin E in Defective Insulin Secretion and Carbohydrate Intolerance in Diabetes Mellitus

R. Paul Robertson, Mei Chen · Journal of Clinical Investigation · 1977 · 143 citations · Full text

Medicine, Endocrinology, Pharmacology +15