Alkaline Phosphatase Promotes Radioprotection and Accumulation of WR-1065 in V79-171 Cells Incubated in Medium Containing WR-2721

Abstract

Addition of alkaline phosphatase and WR-2721 to culture medium containing V79-171 cells leads to production of WR-1065 and its disulphide forms in the medium, to cellular accumulation of WR-1065, and to radioprotection which correlates with cellular WR-1065 level.