Concepedia

Alkaline Phosphatase Promotes Radioprotection and Accumulation of WR-1065 in V79-171 Cells Incubated in Medium Containing WR-2721

Paula M. Calabro-Jones, Robert C. Fahey, Geraldine D. Smoluk, John F. Ward

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · 1985 · 168 citations · 15 references

DOI

Concepts

Abstract

Addition of alkaline phosphatase and WR-2721 to culture medium containing V79-171 cells leads to production of WR-1065 and its disulphide forms in the medium, to cellular accumulation of WR-1065, and to radioprotection which correlates with cellular WR-1065 level.

References

15

International Journal of Radiation Biology

Nature · 1959 · 2K citations · Full text

, , +13

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

John M. Yuhas · PubMed · 1980 · 294 citations

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Interaction of Cultured Mammalian Cells with WR-2721 and Its Thiol, WR-1065: Implications for Mechanisms of Radioprotection

J.W. Purdie, Elizabeth R. Inhaber, Henry Schneider et al. · International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine · 1983 · 131 citations

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Time-dose relationships for 5-fluorouracil cytotoxicity against human epithelial cancer cells in vitro.

Paula M. Calabro-Jones, John E. Byfield, John F. Ward et al. · PubMed · 1982 · 117 citations

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An Experimental and Analytical Study of Oxygen Depletion in Stirred Cell Suspensions

D. W. Whillans, Andrew M. Rauth · Radiation Research · 1980 · 99 citations

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