Toxicity and Cerebrospinal Fluid Levels of Carboplatin Chronically Infused into the Brainstem of a Primate

Convection-enhanced delivery of macromolecules in the brain.

R. Hunt Bobo, Douglas W. Laske, Aytaç Akbaşak et al. · Proceedings of the National Academy of Sciences · 1994 · 1.4K citations

Pharmacy, Neuroscience, Pharmaceutics +16

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Henry Brem, Steven Piantadosi, P. C. Burger et al. · The Lancet · 1995 · 1.4K citations · Full text

Pharmacy, Oncology, Surgery +16

A phase 3 trial of local chemotherapy with biodegradable carmustine(BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma

Manfred Westphal, Dana Hilt, Enoch Bortey et al. · Neuro-Oncology · 2003 · 1.3K citations · Full text

Medicine, Oncology, Surgery +17

Carboplatin and vincristine chemotherapy for children with newly diagnosed progressive low-grade gliomas

R. J. Packer, Jeffrey C. Allen, Peter C. Phillips∥ et al. · Journal of neurosurgery · 1997 · 639 citations

Medicine, Oncology, Pediatrics +16

Interstitial Chemotherapy with Carmustine-loaded Polymers for High-grade Gliomas: A Randomized Double-blind Study

S. Valtonen, UI la Timonen, Petri Toivanen et al. · Neurosurgery · 1997 · 427 citations

Medicine, Neurosurgery, Oncology +15