Therapeutic antibody expression technology

Continuous cultures of fused cells secreting antibody of predefined specificity

Georges Köhler, César Milstein · Nature · 1975 · 17.2K citations

Pharmacy, Cell Biology, Immunology +11

Reshaping human antibodies for therapy

Lutz Riechmann, Herman Waldmann, Greg Winter · Nature · 1988 · 1.6K citations

Pharmacy, Immunology, Pharmaceutical Biotechnology +12

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

Sherie L. Morrison, M J Johnson, L A Herzenberg et al. · Proceedings of the National Academy of Sciences · 1984 · 1K citations · Full text

Pharmacy, Immunology, Molecular Biology +17

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

José Baselga, Larry Norton, Joan Albanell et al. · PubMed · 1998 · 1K citations

Medicine, Oncology, Pharmacology +15

Interleukin-2–Receptor Blockade with Daclizumab to Prevent Acute Rejection in Renal Transplantation

F. Vincenti, Robert L. Kirkman, Susan Light et al. · New England Journal of Medicine · 1998 · 876 citations · Full text

Medicine, Immunology, Pharmacology +17