Studies of cell toxicity and binding of magnetic nanoparticles with blood stream macromolecules

Abstract

In this work, we investigated the interaction between different molecular-coated magnetite-based nanoparticles stabilized as biocompatible magnetic fluids (BMFs) and both serum albumin proteins (HSA and BSA). The investigation was focused on the fluorescence quenching of the tryptophan residue proteins after their binding with the molecular-coated magnetic nanoparticles (MNPs) at specific sites. The results showed distinct association of the BMFs with HSA and BSA, a fact that directly affects the application, biodistribution, and clinical trial therapy using colloidal stabilized MNPs.