Emerging infectious diseases · 2003 · 429 citations · 17 references
Veterinary MedicineInfectious DiseasesPediatricsMedical MicrobiologyPediatric Infectious DiseasesVirologyRespiratory DiseaseRespiratory InfectionsRespiratory Infectious DiseasesRespiratory Tract InfectionsViral EpidemiologyViral InfectionsChildhood Wheezing EpidemiologyHuman Metapneumovirus InfectionPediatric Asthma ExacerbationRespiratory Infection EpidemiologyRespiratory Infections In ChildrenRespiratory Viral InfectionsRespiratory VirusesViral Respiratory Infections
Human metapneumovirus (HMPV) is a newly discovered pathogen associated with respiratory disease. The study aimed to determine the prevalence and clinical impact of HMPV in 587 hospitalized children with respiratory infection over a 13‑month period. The authors examined nasopharyngeal aspirates from these children using reverse transcription‑polymerase chain reaction to detect HMPV. HMPV was found in 5.5% of children and was linked to pneumonia (36%), asthma exacerbation (23%), or bronchiolitis (10%) and was more common in older children with wheezing as asthma rather than bronchiolitis compared to RSV, peaked in spring‑summer, belonged to two known lineages, and contributed 441.6 hospital admissions per 100,000 children under 6.
Abstract Human metapneumovirus (HMPV) is a newly discovered pathogen thought to be associated with respiratory disease. We report the results of a study of 587 children hospitalized with respiratory infection over a 13-month period. HMPV was detected in the nasopharyngeal aspirates from 32 (5.5%) children by reverse transcription-polymerase chain reaction. HMPV infection was associated with clinical diagnoses of pneumonia (36%), asthma exacerbation (23%), or acute bronchiolitis (10%). When compared to those with respiratory syncytial virus infection, children with HMPV infection were older, and wheezing was more likely to represent asthma exacerbation rather than acute bronchiolitis. HMPV viral activity peaked during the spring-summer period in Hong Kong. Phylogenetically, all HMPV virus strains from Hong Kong belonged to one of the two genetic lineages previously described. HMPV contributed to 441.6 hospital admissions per 100,000 population <6 years of age.
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Guy Boivin, Yacine Abed, Gilles Pelletier et al. · The Journal of Infectious Diseases · 2002 · 605 citations · Full text
Analysis of the Genomic Sequence of a Human Metapneumovirus
Bernadette G. van den Hoogen, Theo M. Bestebroer, Albert D. M. E. Osterhaus et al. · Virology · 2002 · 475 citations · Full text