Amyloid beta-protein1-42 increases cAMP and apolipoprotein E levels which are inhibited by β1 and β2-adrenergic receptor antagonists in mouse primary astrocytes

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Warren J. Strittmatter, Ann M. Saunders, D. E. Schmechel et al. · Proceedings of the National Academy of Sciences · 1993 · 4.3K citations · Full text

Type 4, Genetics, Genetic Epidemiology +18

CNS Synaptogenesis Promoted by Glia-Derived Cholesterol

Daniela H. Mauch, Karl Nägler, Stefan Schumacher et al. · Science · 2001 · 1.7K citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

J K Boyles, Robert E. Pitas, Elaine V. Wilson et al. · Journal of Clinical Investigation · 1985 · 817 citations · Full text

Pathology, Apo E, Cellular Neurobiology +23

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

Robert E. Pitas, J K Boyles, Susan H. Lee et al. · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 1987 · 690 citations

Apolipoprotein E, Biochemistry, Lipoprotein Metabolism +6

Expression of apolipoprotein E during nerve degeneration and regeneration.

Michael J. Ignatius, Peter Gebicke-Härter, J. H. Pate Skene et al. · Proceedings of the National Academy of Sciences · 1986 · 564 citations · Full text

Cell Death, Peripheral Nerves, Optic Nerve +19