<i>TigarB</i> causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency - Concepedia

Concepedia

Publication | Open Access

<i>TigarB</i> causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency

DOI Full Paper Access

88

Citations

34

References

2013

Year

Laura Flinn, Marcus Keatinge, Sandrine Bretaud, Heather Mortiboys, Hideaki Matsui, Elena De Felice, Helen I. Woodroof, Lucy Brown, Aimee McTighe, Rosemarie Soellner,

Annals of Neurology

Abstract

Pink1(-/-) zebrafish are the first vertebrate model of PINK1 deficiency with loss of dopaminergic neurons. Our study also identifies TIGAR as a promising novel target for disease-modifying therapy in PINK1-related PD.

References

	Year	Citations

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