Association of <i>ERG</i> and <i>TMPRSS2‐ERG</i> with grade, stage, and prognosis of prostate cancer is dependent on their expression levels

Abstract

Although more studies are needed to further clarify their role, our findings emphasize that the expression levels of the TMPRSS2-ERG fusion and ERG mRNA, rather than their mere presence, are related to a more aggressive phenotype, have an effect on prognosis and could be molecular markers of progression for prostate cancer. Furthermore, ERG immunohistochemistry could be also a potentially useful prognostic factor.