Concepedia

Both MC <sub>1</sub> and MC <sub>3</sub> Receptors Provide Protection From Cerebral Ischemia-Reperfusion–Induced Neutrophil Recruitment

Paul M. Holloway, Pascal F. Durrenberger, Marjan Trutschl, Urška Cvek, Dianne Cooper, A. Wayne Orr, Mauro Perretti, Stephen J. Getting, Felicity N. E. Gavins

Arteriosclerosis Thrombosis and Vascular Biology · 2015 · 28 citations · 22 references

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Abstract

These studies reveal for the first time MC control for neutrophil recruitment in the unique pathophysiological context of cerebral I/R, while also demonstrating the potential therapeutic value of targeting multiple MCs in developing effective therapeutics.

References

22

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Cyclic lactam .alpha.-melanotropin analogs of Ac-Nle4-cyclo[Asp5,D-Phe7,Lys10]-.alpha.-melanocyte-stimulating hormone-(4-10)-NH2 with bulky aromatic amino acids at position 7 show high antagonist potency and selectivity at specific melanocortin receptors

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Early TNF-α levels correlate with ischaemic stroke severity

Jacek Zaremba, Jacek Losy · Acta Neurologica Scandinavica · 2001 · 193 citations