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Dipyrone metabolite 4‐<scp>MAA</scp> induces hypothermia and inhibits <scp>PGE</scp><sub>2</sub>‐dependent and ‐independent fever while 4‐<scp>AA</scp> only blocks <scp>PGE</scp><sub>2</sub>‐dependent fever

DOIFull Paper Access

28

Citations

33

References

2014

Year

David do Carmo Malvar, Fernando Armani Aguiar, Artur de L.L. Vaz, Débora C R Assis, M. C. C. Melo, Valquíria Aparecida Polisel Jabor, Evanguedes Kalapothakis, Sérgio H. Ferreira, Giuliano C. Clososki, Glória Emília Petto de Souza
British Journal of Pharmacology

Abstract

The presence of 4-MAA and 4-AA in the CSF and hypothalamus was associated with PGE2 synthesis inhibition and a decrease in LPS-induced fever. 4-MAA was also shown to be an antipyretic metabolite for PGE2 -independent fever induced by Tsv suggesting that it is responsible for the additional antipyretic mechanism of dipyrone. Moreover, 4-MAA is the hypothermic metabolite of dipyrone.

References

YearCitations

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