PubMed · 1981 · 113 citations · 0 references
MedicineCancer BiologyOncologyCancer PharmacologyChemotherapyMolecular OncologyAntineoplastic Drug InteractionsCytotoxic ChemotherapyDna CrosslinkingDna DamageDna Damage SignalingAntimetabolite CombinationsDna Cross-linkingDna Crosslinking CytotoxicityDrug-induced Dna DamagePlatinum-induced Dna CrosslinksPleiotropic Lethal Effects
cis-Dichlorodiammineplatinum(II) and 1-beta-D-arabinofuranosylcytosine display a dramatic synergistic effect when tested in simultaneous combination on LoVo cells, a human colon carcinoma cell line. 1-beta-D-Arabinofuranosylcytosine alone does not induce any cytotoxicity on LoVo cells even at high concentrations but is able to increase up to 1000 times the lethal effects of cis-dichlorodiammineplatinum(II). DNA elution experiments show that 1-beta-D-arabinofuranosylcytosine increases the amount of cis-dichlorodiammineplatinum(II)-induced DNA cross-links. The possible mechanisms of this effect are discussed, and some explanations are proposed.