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Hepatomas in CBA/Cb/Se Mice and Liver Lesions in Golden Hamsters Induced by Hydrazine Sulfate<xref ref-type="fn" rid="FN2">2</xref>
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1970
Year
PathologyHydrazine SulfateGolden Hamsters InducedHepatic DisordersHepatobiliary TumorToxicologyHepatotoxicityLiver PhysiologyHistopathologyPharmacologyDrug-induced Liver InjuryLiver LesionsHepatologyMg HsHepatitisLiver DiseaseLiver CancerLiverMedicineHepatocellular CarcinomaVirgin Golden Hamsters
Hydrazine sulfate (HS), administered daily in scalar doses to intact virgin CBA/Cb/Se mice of both sexes, raised the hepatoma incidence as follows: 1.13 mg, 60% in males and 62.5% in females; 0.56 mg, 48% in males and 66.6% in females; 0.28 mg, 28% in males and 8% in females; and 0.14 mg, 3.8% in males and 0% in females. Most tumors were highly vascularized hepatocarcinomas; however, 4 mice that received 1.13 mg HS daily also had lung metastases. HS administered to intact virgin golden hamsters of both sexes caused liver reticuloendothelial cell proliferation and cirrhosis, bile duct proliferation, and degeneration of fibrous cells in the hyalinized sclerotic tissue. But no liver lesions were observed in the untreated controls.