Can the de Lange syndrome always be diagnosed at birth?

Abstract

The comment ... The children are diagnosable at birth. This resemblance to one another is as striking to us as the resemblance of mongols to each other1 holds true for most, but not all cases of the de Lange syndrome.2,3 This paper will describe a patient who at the age of 9 months had features suggestive of Turner9s syndrome, and at the age of 21 months had the typical appearance of the de Lange syndrome. Case Report The patient, a Caucasian female, was the third child of unrelated parents who were 28 and 30 years old respectively when she was born January 29, 1968.