Concepedia

The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease

Grégoire Michaux, Dominique Massey‐Harroche, Ophélie Nicolle, Marion Rabant, Nicole Brousse, Olivier Goulet, André Le Bivic, Frank M. Ruemmele

Biology of the Cell · 2015 · 34 citations · 29 references

DOIFull text

Open access

Abstract

Our results show that polarity determinants could be useful markers to help establishing a diagnosis in patients. Furthermore, they could be used to characterise other rare intestinal absorption diseases.

References

29

Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line caco-2: Evidence for glucose-dependent negative regulation

Isabelle Chantret, Annie Rodolosse, Alain Barbat et al. · Journal of Cell Science · 1994 · 425 citations

MYO5B mutations cause microvillus inclusion disease and disrupt epithelial cell polarity

Thomas Müller, Michael W. Hess, Natalia Schiefermeier-Mach et al. · Nature Genetics · 2008 · 370 citations

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Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

Aron B. Jaffe, Noriko Kaji, Joanne Durgan et al. · The Journal of Cell Biology · 2008 · 324 citations · Full text

, , +15

TTC7A mutations disrupt intestinal epithelial apicobasal polarity

Amélie Bigorgne, Henner F. Farin, Roxane Lemoine et al. · Journal of Clinical Investigation · 2013 · 196 citations

, , +24

Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease

Caroline L. Wiegerinck, Andreas Janecke, Kerstin Schneeberger et al. · Gastroenterology · 2014 · 172 citations · Full text

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