Concepedia

Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen

Galina Borisova, Bikas K. Arya, Andris Dišlers, V. Tsibinogin, Dace Skrastiņa, Michael A. Eldarov, Paul Pumpens, K. G. Skryabin, Elmars Grens

Journal of Virology · 1993 · 54 citations · 25 references

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Abstract

A hepatitis B core antigen (HBcAg) gene bearing the 39-amino-acid-long domain A of hepatitis B surface antigen (HBsAg) within the HBcAg immunodominant loop has been constructed and expressed in Escherichia coli. Chimeric capsids demonstrated HBs but not HBc antigenicity and elicited in mice B-cell and T-cell responses against native HBcAg and HBsAg.

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