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Histopathology of Liver Carcinomas in (C57BL/6N × C3H/HeN)F<sub>1</sub> Mice Ingesting Chlordane<xref ref-type="fn" rid="fn2">2</xref>
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1979
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C57bl/6n × C3h/henPathologyHepatic DisordersHepatobiliary TumorSurgical PathologyMice Ingesting ChlordanePpm ChlordaneToxicologyHepatotoxicityRadiation OncologyCancer ResearchHealth SciencesLiver PhysiologyHistopathologyC57bl/6n X C3h/henPharmacologyLiver CarcinomasHepatologyLiver DiseaseLiver CancerMedicineHepatocellular CarcinomaF1 Male Mice
(C57BL/6N X C3H/HeN)F1 male mice that ingested 30 or 56 ppm chlordane and female mice that ingested 30 or 64 ppm chlordane in the diet had highly significant incidences of carcinomas of the liver. The carcinomas varied from well differentiated to poorly differentiated and undifferentiated and were capable of invasion and metastasis. They were more poorly differentiated in mice receiving chlordane than in controls.