The blockade of transient receptor potential ankirin 1 (<scp>TRPA</scp>1) signalling mediates antidepressant‐ and anxiolytic‐like actions in mice

Abstract

The present findings indicate that genetic deletion or pharmacological blockade of TRPA1 produces inhibitory activity in mouse models of anxiety and depression. These results imply that TRPA1 exerts tonic control, promoting anxiety and depression, and that TRPA1 antagonism has potential as an innovative strategy for the treatment of anxiety and mood disorders.