Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol‐sensitive<scp>TRPC</scp>cation channels

Abstract

Our results confirm the role of TRPC6 channels in hypoxic pulmonary vasoregulation and indicate that these channels are unlikely to play a major role in BP regulation in SHR. SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo.