JNCI Journal of the National Cancer Institute · 1973 · 166 citations · 0 references
MedicinePharmacologyToxicologyCancer PharmacologyCancer PreventionCarcinogenesisChemical CarcinogenesisLung CancerMalignant NeoplasmsPulmonary ToxicityPulmonary ToxicologyRespiratory ToxicologyBha ToxicityBiological ExposuresChemical Carcinogen ExposureLung CarcinogenesisMechanisms Of Chemical CarcinogenesisMechanisms Of Lung ToxicityPulmonary NeoplasiaPulmonary Toxicity Mechanisms
The antioxidant, butylated hydroxyanisole (BHA), inhibited chemical carcinogen-induced pulmonary adenoma formation of the mouse under 2 experimental conditions: 1) Addition of BHA to the diet protected against pulmonary neoplasia resulting from acute exposures to 7,12-dimethylbenz[a]anthracene (DMBA), benzo[a]pyrene, urethan, or uracil mustard. 2) Addition of BHA to diets containing DMBA, 7-hydroxymethyl-12-methylbenzlalanthracene, or dibenz[a,h]anthracene likewise inhibited pulmonary tumor formation.