The Journal of Immunology · 2001 · 467 citations · 35 references
Innate Immune SystemImmunologyToll-like ReceptorInnate ImmunityWhereas Tlr4InflammationToll-like ReceptorsCell SignalingPhenol-soluble ModulinAllergyAutoimmune DiseaseInflammatory ResponseAutoimmunityHost-microbe InteractionCell BiologyMolecular ImmunologySignal TransductionFunctional InteractionsMicrobiologyCellular Immune ResponseMedicine
Toll-like receptor (TLR) 2 and TLR4 play important roles in the early, innate immune response to microbial challenge. TLR2 is preferentially involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a variety of microbes, whereas TLR4 is essential for a complete response to LPSs. We report here that TLR2 transduces the response to phenol-soluble modulin, a factor secreted by Staphylococcus epidermidis. The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors. We also demonstrate that a response to phenol-soluble modulin mediated by TLR2 and TLR6 was more refractory to inhibition by TLR1 than one mediated by TLR2 alone.
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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene
Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.5K citations