CEP-1347/KT-7515, an Inhibitor of c-jun N-Terminal Kinase Activation, Attenuates the 1-Methyl-4-Phenyl Tetrahydropyridine-Mediated Loss of Nigrostriatal Dopaminergic Neurons In Vivo

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

Jonathan A. Javitch, Robert J. D’Amato, Stephen M. Strittmatter et al. · Proceedings of the National Academy of Sciences · 1985 · 1.3K citations · Full text

Medicine, Neuroscience, Pharmacology +17

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

William J. Nicklas, I Vyas, Richard E. Heikkila · Life Sciences · 1985 · 1.3K citations

Life Sciences, Biochemistry, Neuroscience +14

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Derek Yang, Chia‐Yi Kuan, Alan J. Whitmarsh et al. · Nature · 1997 · 1.2K citations

Life Sciences, Neurobiology, Neuroscience +14

Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo

A. Tomac, Elisabet Lindqvist, L. Lin et al. · Nature · 1995 · 1.1K citations

Life Sciences, Neurobiology, Neuroscience +12

Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors

Richard E. Heikkila, Lawrence Manzino, Felicitas S. Cabbat et al. · Nature · 1984 · 1K citations

Medicine, Neuroscience, Pharmacology +14