Concepedia

Luteolin inhibits myelin basic protein‐induced human mast cell activation and mast cell‐dependent stimulation of Jurkat T cells

D. Kempuraj, Michael Tagen, B P Iliopoulou, Anthony Clemons, Magdalini Vasiadi, William Boucher, Michael House, Adam Wolfberg, Theoharis C. Theoharides

British Journal of Pharmacology · 2008 · 107 citations · 43 references

DOIFull text

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Abstract

Mast cells can stimulate activated Jurkat cells. This interaction is inhibited by luteolin, suggesting that this flavonoid may be useful in the treatment of autoimmune diseases.

References

43

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

Christopher Lock, G Hermans, Rosetta Pedotti et al. · Nature Medicine · 2002 · 1.7K citations

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Interactions of Mast Cell Tryptase with Thrombin Receptors and PAR-2

Marina Molino, Elliot S. Barnathan, Robert P. Numerof et al. · Journal of Biological Chemistry · 1997 · 588 citations · Full text

Mast Cells Enhance T Cell Activation: Importance of Mast Cell Costimulatory Molecules and Secreted TNF

Susumu Nakae, Hajime Suto, Motoyasu Iikura et al. · The Journal of Immunology · 2006 · 422 citations

Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells

Duraisamy Kempuraj, B. Madhappan, Spyridon Christodoulou et al. · British Journal of Pharmacology · 2005 · 335 citations · Full text

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Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosis

Fengmin Lu, Mary Selak, John O’Connor et al. · Journal of the Neurological Sciences · 2000 · 329 citations

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