MedicineBiochemistryDermatologyAgingDermatopathologyPhotodermatologyActinic KeratosisPhotosensitivity DisordersSkin CareSun ProtectionUltraviolet Radiation BiologyUltraviolet Radiation ProtectionActinic DegenerationAging Skin ChangesCutaneous Phototoxic ReactionsDermatological PhotoprotectionPhotosensitive DermatosesRadiation-induced Free RadicalsSkin CarcinogenesisUltraviolet Radiation Damage
UV irradiation of the skin leads to the induction of free radicals, carcinogenesis, and skin aging, and thus the use of beta-carotene in humans as a chaperoning agent is discussed. In the photohemolysis model, beta-carotene protects against the phototoxic effects of porphyrins. Beta-carotene should be used in erythropoietic protoporphyria, photosensitive diseases, and to reduce the effects of phototoxic drugs. Its effects on aging skin and on actinic keratosis have not yet been sufficiently studied.
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Charles H. Hennekens, Julie E. Buring, JoAnn E. Manson et al. · New England Journal of Medicine · 1996 · 2.4K citations · Full text
β-Carotene: an Unusual Type of Lipid Antioxidant
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