Negative feedback–defective PRPS1 mutants drive thiopurine resistance in relapsed childhood ALL

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Medicine, Genetics, Molecular Biology +13

Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

Charles G. Mullighan, Letha A. Phillips, Xiaoping Su et al. · Science · 2008 · 810 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Molecular response to treatment redefines all prognostic factors in children and adolescents with B-cell precursor acute lymphoblastic leukemia: results in 3184 patients of the AIEOP-BFM ALL 2000 study

Valentino Conter, Claus R. Bartram, Maria Grazia Valsecchi et al. · Blood · 2010 · 786 citations · Full text

Medicine, Hematology, Oncology +11

A novel retinoblastoma therapy from genomic and epigenetic analyses

Jinghui Zhang, Claudia A. Benavente, Justina McEvoy et al. · Nature · 2012 · 513 citations · Full text

Medicine, Genetics, Oncology +17

Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL

Gannie Tzoneva, Arianne Pérez-García, Zachary Carpenter et al. · Nature Medicine · 2013 · 351 citations

Medicine, Genetics, Oncology +10