Publication | Closed Access
Lifespan and Incidence of Cancer and Other Diseases in Selected Long-Lived Inbred Mice and Their F1 Hybrids2
175
Citations
0
References
1973
Year
F1 Hybrid CombinationsAgingTumor IncidenceGeneticsGenetic EpidemiologyPathologyBiogerontologyTumor BiologyOncologyTumor HeterogeneityLongevityTheir F1 Hybrids2Public HealthCancer ResearchLifespan ExtensionKnockout MouseOncogenic AgentF1 Hybrid GroupsCancer EpidemiologyGerm CellCellular SenescenceOther DiseasesMedicine
Survival patterns and tumor incidence are presented for long-lived mouse strains LP, 129, DBA/2, CBA, C57BL/10, C3H, and C3H.K and 8 derived F1 hybrid groups. In almost all strains, males lived longer than females. Overall, the F1 hybrid combinations of noncongenic parents had not only an increased tumor incidence but also an increased lifespan. The lifespan and age-specific incidence of cancer observed for the F1 hybrids could not be accurately predicted from the parental characteristics.