<i>In vitro</i> and <i>in vivo</i> pharmacological characterization of nociceptin/orphanin <scp>FQ</scp> tetrabranched derivatives

Abstract

The results showed that the PWT can be successfully applied to the peptide sequence of N/OFQ to generate tetrabranched derivatives characterized by a pharmacological profile similar to the native peptide and associated with a higher potency and marked prolongation of action in vivo.