Efficient production of hyperpolarized bicarbonate by chemical reaction on a <scp>DNP</scp> precursor to measure p<scp>H</scp>

Abstract

Through a rapid chemical reaction, we can conserve the nuclear spin order of a DNP precursor to generate multiple hyperpolarized bioprobes otherwise unamenable to polarization. This indirect technique for the production of hyperpolarized agents can be applied to different precursor compounds to generate additional novel probes.