Osteoinduction in the Presence of Chitosan-Coated Porous Hydroxyapatite

Abstract

Hydroxyapatite nails, prepared according to a novel method and endowed with better mechanical resistance, were coated with chitosan to impart enhanced biocompatibility and were introduced in the femurs of rabbits. Chitosan was found to be a favorable interface between bone and hydroxyapatite because it promoted an osteoconductive reaction.