Concepedia

Base-Promoted Cross-Dehydrogenative Coupling of Quinoline <i>N</i>-Oxides with 1,3-Azoles

Xiaopei Chen, Xiuling Cui, Fangfang Yang, Yangjie Wu

Organic Letters · 2015 · 75 citations · 59 references

DOI

Concepts

Abstract

An efficient cross-dehydrogenative coupling of quinoline N-oxides and 1,3-azoles has been developed under external oxidant and metal free conditions. The desired products were isolated in good to excellent yields for 26 examples. This methodology provides a practical pathway to biheteroaryls and features high practicality, high efficiency, and environmental friendliness.

References

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