Spectrophotometric Determination of Some n-Donating Drugs Using DDQ

Abstract

Abstract Abstract A simple sensitive spectrophotometric method is described for determination of six drugs with different n-donating groups. These drugs are azithromycin (I), ketoconazole (II), clotrimazole (III), clozapine (IV), oxamniquine (V), and pimozide (VI). The method depends on the interaction of these compounds with 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as π acceptor to form highly colored reaction product. The analytical wavelength chosen is 588 nm which gives maximum sensitivity. Optimum conditions for the reaction were determined and the mean percentage recoveries were 99.79 ± 0.65, 100.44 ± 1.03, 100.12 ± 0.66, 99.60 ± 0.8,99.74 ± 0.65 and 100.29 ± 0.79 for I, II, III, IV, V and VI, respectively. Study of the reaction product showed that charge transfer complex (CT) primarily formed dissociates to give radical anion with λmax at 429 nm. The effect of basic properties of the studied drugs, on the production of radical anion, was illustrated by determining the yield percentage and confirmed through the calculation of the rate constant (K) and the association constant (KCT AD). The proposed method was applied successfully to the determination of the six drugs in both reference material as well as dosage forms with high accuracy and precision. The results were compared with those obtained by the official and reference methods. Key Words: Charge transfer complexπ acceptorAzithromycinKetoconazoleClotrimazoleClozapineOxamniquinePimozideSpectrophotometry.