PubMed · 1953 · 407 citations · 6 references
Life SciencesBiochemistryOncologyCellular MetabolismLipid BiochemistryMetabolismCancer MetabolismFatty Acid BiosynthesisFatty Acid MetabolismFatty Acid SynthesisLipid BiosynthesisLipid MetabolismCancer Cell LipogenesisFatty Acid Biosynthesis In DiseaseFatty Acid Chain ElongationFatty Acid Precursor BiosynthesisMetabolic Alterations In CancerNeoplastic DiseaseTumor Cell MetabolismTumor Metabolism
Summary A study of lipogenesis in neoplastic tissues has shown that acetate and glucose carbon can be utilized for synthesis of the fatty acid chain. However, the data indicate that this process is probably too slow to supply the lipid needs of a rapidly growing tumor, and the tumor must therefore obtain its lipids preformed from the host.
6
Paul C. Zamecnik, Ivan D. Frantz, Robert B. Loftfield et al. · Journal of Biological Chemistry · 1948 · 122 citations · Full text
Studies on the carbohydrate and protein metabolism of the rat hepatoma.
Paul C. Zamecnik, Robert B. Loftfield, Mary L. Stephenson et al. · PubMed · 1951 · 94 citations