Altered Disposition and Antinociception of [d-Penicillamine2,5] Enkephalin in mdr1a-Gene-Deficient Mice

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

Alfred H. Schinkel, Els Wagenaar, Carla A.A.M. Mol et al. · Journal of Clinical Investigation · 1996 · 1.3K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +15

Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

Alfred H. Schinkel, Els Wagenaar, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1995 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

The multidrug transporter, a double-edged sword.

Michael M. Gottesman, I Pastan · Journal of Biological Chemistry · 1988 · 766 citations · Full text

Life Sciences, Pharmacology, Intracellular Transport +10

Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.

Henry I. Mosberg, R. P. Hurst, Victor J. Hruby et al. · Proceedings of the National Academy of Sciences · 1983 · 739 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17