Toll‐like receptor 4 contributes to vascular remodelling and endothelial dysfunction in angiotensin <scp>II</scp>‐induced hypertension

Abstract

TLR4 up-regulation by AngII contributed to the inflammation, endothelial dysfunction, vascular remodelling and stiffness associated with hypertension by mechanisms involving oxidative stress. MyD88-dependent activation and JNK/NF-κB signalling pathways participated in these alterations.