Concepedia

Phase IIB/III Trial of Tenecteplase in Acute Ischemic Stroke

E. Clarke Haley, John L.P. Thompson, James C. Grotta, Patrick D. Lyden, Thomas Hemmen, Devin L. Brown, Christopher Fanale, Richard Libman, Thomas Kwiatkowski, R. Llinás,

Stroke · 2010 · 271 citations · 9 references

DOI

Abstract

This prematurely terminated trial has demonstrated the potential efficiency of a novel design in selecting a propitious dose for future study of a new thrombolytic agent for acute stroke. Given the truncation of the trial, no convincing conclusions can be made about the promise of future study of tenecteplase in acute stroke.

References

9

Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.

Harold P. Adams, Birgitte H. Bendixen, L. Jaap Kappelle et al. · Stroke · 1993 · 12K citations · Full text

Interobserver agreement for the assessment of handicap in stroke patients.

John C. van Swieten, Peter J. Koudstaal, Marieke C. Visser et al. · Stroke · 1988 · 6.3K citations · Full text

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Guidelines for the Early Management of Adults With Ischemic Stroke

Harold P. Adams, Gregory del Zoppo, Mark J. Alberts et al. · Stroke · 2007 · 2.5K citations

Single-bolus tenecteplase compared with front-loaded alteplase in acute myocardial infarction: the ASSENT-2 double-blind randomised trial

Frans Van de Werf · The Lancet · 1999 · 876 citations

, , +11

A Pilot Dose-Escalation Safety Study of Tenecteplase in Acute Ischemic Stroke

E. Clarke Haley, Patrick D. Lyden, Karen C. Johnston et al. · Stroke · 2005 · 220 citations · Full text