Concepedia

Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model

Ting Zhao, Hasan B. Alam, B. Liu, Rod T. Bronson, Vahagn C. Nikolian, Erxi Wu, Weelic Chong, Yan Li

Current Molecular Medicine · 2015 · 46 citations · 26 references

DOIFull text

Open access

Abstract

Selective inhibition of SIRT2 significantly improves survival, and attenuates sepsis-associated "cytokine storm", coagulopathy, and bone marrow atrophy in a mouse model of lethal septic shock.

References

26

Heat Shock Protein A12B Protects Vascular Endothelial Cells Against Sepsis-Induced Acute Lung Injury in Mice

Yi Chen, Lei Wang, Qiuxiang Kang et al. · Cellular Physiology and Biochemistry · 2017 · 10.7K citations · Full text

Immunodesign of experimental sepsis by cecal ligation and puncture

Daniel Rittirsch, Markus Huber‐Lang, Michael A. Flierl et al. · Nature Protocols · 2008 · 2.1K citations · Full text

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Extrachromosomal rDNA Circles— A Cause of Aging in Yeast

David Sinclair, Leonard Guarente · Cell · 1997 · 1.5K citations · Full text

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The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

Brian J. North, Brett Marshall, Margie T. Borra et al. · Molecular Cell · 2003 · 1.5K citations · Full text

, , +7

Sirtuin 2 Inhibitors Rescue α-Synuclein-Mediated Toxicity in Models of Parkinson's Disease

Tiago F. Outeiro, Eirene Kontopoulos, Stephen M. Altmann et al. · Science · 2007 · 1K citations · Full text

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