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Late Radiation Nephritis after Gastric X-Irradiation for Peptic Ulcer<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>
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1971
Year
Gastric IrradiationGastric X-irradiationLate Radiation NephritisRenal PathologyGastroenterologyInterventional RadiologyRadiation MedicineRenal FunctionSurgical PathologyChronic Kidney DiseaseRadiation OncologyNuclear MedicineRadiologyHealth SciencesSignificant ShrinkageRadiological SciencesRadiation TherapyKidney FailureBenign HypertensionRenal PathophysiologyRadiologic ImagingPeptic UlcerUrologyMedicineNephrology
A review of 84 patients treated by limited gastrectomy and moderate doses (about 2000 r) of irradiation to the stomach revealed 31 with evidence of renal disease 8–19 years later: seven died of uraemia and two of malignant hypertension. The latent interval between gastric irradiation and discovery of renal disease was one to 14 years. The 31 patients with presumed radiation-induced renal disease were grouped as follows: chronic renal failure, 5 patients; malignant hypertension, 4 patients; benign hypertension, 11 patients; biochemical evidence of renal disease, 11 patients. Measurement of renal length radiologically and renal weight at necropsy showed significant shrinkage of the left kidney as compared with the right, and the degree of shrinkage was somewhat proportional to the dose of radiation. The basic pathological lesions as determined from seven necropsy and six biopsy specimens were interstitial nephritis with degenerative changes of the small and medium sized arteries, indicating that the primary radiation effect was damage to the renal blood vessels.